Nano Assault

Nano Assault is a 3D shoot 'em up where players pilot a microscopic ship through 32 cell stages and rugged landscapes to destroy a deadly virus threatening humanity. The game features explorable 3D instances blended with Star Fox-style shooting and adjusts difficulty based on player skill. It is a spiritual successor to the Nanostray series, with smooth controls using the Circle Pad and face buttons for movement and firing. Modes include single-player story progression, plus later additions like arcade and boss rush. The story follows nanomachines sent into a cellular system to stop the Nanostray virus. It stands out for its visually stunning full-3D graphics that leverage the 3DS screens effectively, with great level design and fair difficulty curve.